iovera°_®

GET RELIEF IN MOTION WITH iovera°

Immediate and long-lasting pain relief using advanced cold technology¹

A COOL WAY TO MANAGE KNEE PAIN

iovera° relieves pain before and after surgery

Everyone is familiar with the use of cold for pain relief. But iovera° uses cold like no other therapy. It is a safe, FDA-cleared treatment that uses extreme cold to stop nerves from sending pain signals. This relief is immediate and can last up to 90 days.^1,2

Standing up to knee pain could mean more activity

When your knee is hurting, it can limit what you feel comfortable doing in your everyday routine.³ With lasting pain relief, you’re more likely to get back to the basic activities you want to do.⁴

Why choose iovera°?

FDA=US Food and Drug Administration; OA=osteoarthritis.

HOW DOES iovera° WORK?

iovera° is a handheld device that lets your doctor apply just the right amount of extreme cold only to the nerves they want to target—the ones causing you pain. The iovera° treatment is localized, non-surgical, and does not contain medicine or opioids.^1,2

1. A numbing agent (topical or injected) is applied to minimize discomfort during treatment.
2. A small needle is inserted into the skin to deliver precise, controlled doses of cold directly to the targeted nerves. This immediately blocks the nerves from sending pain signals.
3. The process is complete when the targeted nerves causing your pain are blocked.

HAVE OA KNEE PAIN?

FEEL BETTER WITH UP TO 90 DAYS OF RELIEF¹

When you’re living with OA of the knee, it’s a relief to know there’s a drug-free option like iovera° that can immediately reduce your chronic pain:

A clinical study of patients with knee OA treated with iovera° compared with those who received a placebo treatment.

HAVING KNEE REPLACEMENT SURGERY?

GET BACK ON THE MOVE

While surgery may be in your future, your recovery doesn’t have to be painful. Patients who received iovera° before surgery had:

Two clinical studies of patients who had knee replacement surgery treated with iovera° compared with those who received standard-of-care treatment without iovera°.

HAVE QUESTIONS ABOUT iovera°?

What makes iovera° different from other pain treatments?

iovera° is an innovative type of pain-relief treatment known as cryoneurolysis (kri-o-nuh-rol-i-sis), or cold therapy. It uses targeted cold to temporarily stop nerves from sending pain signals to the brain.

What kind of results can I expect?

Pain relief from the iovera° treatment can be felt immediately after treatment. When the treatment is applied to a specific nerve, it will interrupt that nerve’s ability to send a pain signal, providing an immediate reduction in pain.

Does the iovera° treatment hurt?

The iovera° treatment should not be painful. An injection or topical numbing medication will be used on the treatment area to manage any potential discomfort. Some people describe feeling pressure or tugging during the iovera° treatment. Cold, warm, and tingling sensations are also normal, as is some level of discomfort. Tell your doctor right away if you feel any pain during your treatment.

Individual patient results may vary.

MORE ANSWERS TO COMMON QUESTIONS

Are there any side effects?

Side effects from iovera° may include bruising, swelling, inflammation and/or redness, local pain and/or tenderness, and altered feeling at the application site (the knee). Typically, these reactions are mild and resolve with no physician intervention. Ask your health care provider if you have concerns about side effects.

Is the iovera° treatment permanent?

No. The iovera° system uses nitrous oxide, which is not able to reach a temperature cold enough to permanently stop the nerve from signaling. The treatment can last up to 90 days, and patients are able to go back to their doctors to receive additional treatments as needed.

How do I know if the iovera° treatment is right for me?

iovera° is an option for people who are experiencing OA pain in the knee. It can also be given before or after knee replacement surgery to make recovery easier and less painful. Ask your doctor about iovera° if you have tried other pain treatments for OA, or if you are discussing having knee replacement surgery.

• An option for long-lasting management of OA knee pain and pre-/postsurgical pain
• Targeted to relieve the pain in your knee, so it does not affect your entire body like opioids or other medications
• FDA-cleared to block pain

References: 1. Radnovich R, Scott D, Patel AT, et al. Cryoneurolysis to treat the pain and symptoms of knee osteoarthritis: a multicenter, randomized, double-blind, sham-controlled trial. Osteoarthritis Cartilage. 2017;25(8):1247-1256. 2. American Academy of Orthopaedic Surgeons. Management of Osteoarthritis of the Knee (Non-Arthroplasty). Evidence-Based Clinical Practice Guideline. https://www.aaos.org/oak3cpg. Published August 31, 2021. Accessed November 15, 2023. 3. Kaila-Kangas L, Leino-Arjas P, Koskinen A, et al. Sickness absence and return to work among employees with knee osteoarthritis with and without total knee arthroplasty: a prospective register linkage study among Finnish public sector employees. Scand J Work Environ Health. 2021;47(8):600-608. 4. Skou ST, Pedersen BK, Abbott JH, Patterson B, Barton C. Physical activity and exercise therapy benefit more than just symptoms and impairments in people with hip and knee osteoarthritis. J Orthop Sports Phys Ther. 2018;48(6):439-447. 5. Urban JA, Dolesh K, Martin E. A multimodal pain management protocol including preoperative cryoneurolysis for total knee arthroplasty to reduce pain, opioid consumption, and length of stay. Arthroplast Today. 2021;12(10):87-92. 6. Dasa V, Lensing G, Parsons M, Harris J, Volaufova J, Bliss R. Percutaneous freezing of sensory nerves prior to total knee arthroplasty. Knee. 2016;23(3):523-528. 7. Plessl D, Salomon B, Haydel A, Leonardi C, Bronstone A, Dasa V. Rapid versus standard recovery protocol is associated with improved recovery of range of motion 12 weeks after total knee arthroplasty. J Am Acad Orthop Surg. 2020;28(21):e962-e968. doi:10.5435/JAAOS-D-19-00597.

For iovera° Important Safety Information, please visit iovera.com/risks.